14th August 2020

A 5-year-old child with Down syndrome presents with fatigue, dyspnoea, a petechial rash and weight loss

A 5-year-old child with Down syndrome presents with fatigue, dyspnoea, a petechial rash and weight loss over the last two weeks. On examination, you can palpate multiple painless widespread enlarged lymph nodes as well as an enlarged liver and spleen. She is diagnosed with acute lymphoblastic leukaemia, t(9;22) negative. Which therapy option will be most appropriate to induce remission?

Select the SINGLE most appropriate option from the list below. Select ONE option only.