1st June 2026

Ms Sarah Matthews, a 50-year-old female with unstable angina, is admitted to the hospital after presenting with chest pain at rest for the last 12 hours.

Ms Sarah Matthews, a 50-year-old female with unstable angina, is admitted to the hospital after presenting with chest pain at rest for the last 12 hours. She is not hypertensive, but she has a family history of coronary artery disease. She is started on dual antiplatelet therapy with aspirin and clopidogrel. After 5 days of therapy, her platelet count drops to 9 x 10^9/L (severe thrombocytopenia). Her INR is normal, and she has no signs of active bleeding. What is the most appropriate management for her?

Select the SINGLE most appropriate option from the list below. Select ONE option only.