27th August 2023

A 45-year-old woman is admitted to the Intensive Care Unit with severe sepsis secondary to a urinary tract infection

A 45-year-old woman is admitted to the Intensive Care Unit with severe sepsis secondary to a urinary tract infection. She has become increasingly oliguric over the past few hours, and the nurse alerts you to a sudden drop in her blood pressure. Her observations are a heart rate of 120 bpm, blood pressure of 80/50 mmHg, and temperature of 38.5°C. She also has petechiae on her skin. Laboratory results show thrombocytopenia, prolonged PT and APTT, elevated D-dimers, and reduced fibrinogen.

What is the most likely diagnosis?