14th May 2024

A 28-year-old woman, diagnosed with major depressive disorder, reports feeling persistently sad, fatigued, and worthless.

A 28-year-old woman, diagnosed with major depressive disorder, reports feeling persistently sad, fatigued, and worthless. Despite treatment with an antidepressant for the past three months, her symptoms have shown minimal improvement.

Which factor is most likely contributing to the lack of significant response to the medication?