30th April 2024

A 32-year-old woman presents with a 4-week history of weight loss, intermittent fever, and night sweats.

A 32-year-old woman presents with a 4-week history of weight loss, intermittent fever, and night sweats. She reports a dry cough and generalised weakness. She has a past medical history of recurrent herpes simplex virus infections. She is sexually active with multiple partners and does not regularly use protection.

Investigations:

Temperature: 38.5°C

Respiratory Rate: 22 breaths/min

Blood Pressure: 110/70 mmHg

Physical Examination: Generalised lymphadenopathy, oral candidiasis

Which is the most appropriate diagnostic investigation?