25th May 2025

A 34-year-old female presents to the endocrinology clinic with worsening tremors and palpitations over the course of 2 months.

A 34-year-old female presents to the endocrinology clinic with worsening tremors and palpitations over the course of 2 months. She notes that she has also unintentionally lost approximately 4kg in weight and has recently been diagnosed with anxiety. She notes that her period has become lighter. She also reports that her eyes have been feeling increasingly dry, requiring multiple applications of lubricating eye drops.

Examination reveals a fine tremor and tachycardia. A diffuse goitre was felt on palpation. On examination of her eyes, bilateral proptosis was noted. Periorbital oedema was also noted.

Given the likely diagnosis, which of the following autoantibodies is most likely to cause the underlying condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.