25th May 2025

A 40-year-old male presents to the acute medical unit with a 4-day history of double vision, incoordination and weakness.

A 40-year-old male presents to the acute medical unit with a 4-day history of double vision, incoordination and weakness. He states that his weakness began in his lower limbs and gradually spread to his upper limbs over 48 hours. Examination reveals a lateral rectus palsy in his left eye with associated lateral gaze nystagmus.

He also exhibited past pointing and intention tremor bilaterally. Global areflexia and weakness of 3/5 in all muscle groups were noted. Sensory examination revealed loss of fine touch and vibration sensation distally. He was recently admitted with diarrhoea and fevers, and he was well before discharge five days ago.

Which of the following autoantibodies is associated with this condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.