3rd May 2024

A 40-year-old man with a history of C282Y homozygosity is diagnosed with haemochromatosis after presenting with fatigue, arthralgia, and elevated liver enzymes.

A 40-year-old man with a history of C282Y homozygosity is diagnosed with haemochromatosis after presenting with fatigue, arthralgia, and elevated liver enzymes. Laboratory tests confirm elevated serum transferrin saturation and ferritin levels. He has no evidence of organ damage.

Which is the most appropriate first-line treatment?