4th May 2024

A 43-year-old woman presents to her GP with a six-month history of persistent low mood, decreased appetite, and difficulty concentrating.

A 43-year-old woman presents to her GP with a six-month history of persistent low mood, decreased appetite, and difficulty concentrating. She mentions feeling hopeless and admits to experiencing thoughts of self-harm. She has a history of hypertension, for which she takes medication. There is no history of substance abuse or psychiatric treatment. The GP considers starting her on an antidepressant.

What is the single most appropriate initial antidepressant treatment for this patient?