25th May 2025

A 45-year-old female presents with jaundice and fatigue.

A 45-year-old female presents with jaundice and fatigue. This was also accompanied by intense itchiness throughout her body. This does not settle with emollients. Abdominal examination showed mild hepatomegaly. Blood tests reveal elevated levels of bilirubin, cholesterol and ALP. Anti-mitochondrial antibodies and ANA were positive. She tested negative for hepatitis B, C and HIV.

What is the likely diagnosis?

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