5th May 2024

A 45-year-old man presents to the emergency department with a high fever, severe headache, neck stiffness, and altered mental status.

A 45-year-old man presents to the emergency department with a high fever, severe headache, neck stiffness, and altered mental status. He has no known allergies and no significant medical history. Lumbar puncture is planned but there will be a delay.

Which is the most appropriate initial management?