28th May 2025

A 52 year old man attends an urgent haematology appointment.

A 52 year old man attends an urgent haematology appointment. He saw his GP with a several month history of generalised lymphadenopathy, hepatosplenomegaly, widespread skin lesions, and general malaise. His blood tests demonstrated severe lymphocytosis and moderate hypercalcaemia.

The haematologist suspects adult-onset T-cell leukaemia.

Which of the following options best describes the pathophysiology of this disease?

Select the SINGLE most appropriate option from the list below. Select ONE option only.