30th April 2024

A 55-year-old man presents with a four-month history of epigastric pain, particularly at night and when hungry.

A 55-year-old man presents with a four-month history of epigastric pain, particularly at night and when hungry. The pain is relieved by eating or taking antacids. He denies weight loss, vomiting, or gastrointestinal bleeding but has a history of occasional ibuprofen use for chronic knee pain. His physical examination is unremarkable except for mild epigastric tenderness.

Which investigation is most appropriate to confirm the diagnosis of peptic ulcer disease?