1st February 2024

Pathophysiology

Presenile Alzheimer’s dementia can run in families and is autosomal dominant. It can be due to mutations of presenilin 1 or 2 genes.
Likewise, frontotemporal lobar degeneration can occur in individuals between ages 45 and 65 usually and could be due to genetic causes, especially involving a mutation of tau genes.
Huntington’s dementia can be caused due to expansion of the CAG repeat sequence. It is inherited as an autosomal dominant condition.
Vascular dementia due to physical morbidities can also be responsible.
Cerebral vasculitis is one of the treatable causes

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