15th April 2024

Aetiology

Kallman syndrome is a clinically and genetically heterogenous condition with ~60% of cases occurring due to sporadic mutations (1), inherited Kallman syndrome has different patterns of inheritance (Autosomal recessive, Autosomal dominant and X-chromosome recessive(1)). There are several different genes associated with Kallman syndrome, with the most common mutations occurring in the ANOS1 and FGFR1 genes (4)