15th September 2024

Clinical features

Typical symptoms and signs related to body composition include increased body fat, particularly central adiposity, decreased muscle mass and decreased muscle function.

Features related to cardiovascular and metabolic health include poor thermoregulation, decreased insulin sensitivity, increased total and LDL cholesterol and Apo B, decreased HDL cholesterol, accelerated atherogenesis, impaired cardiac function and decreased exercise capacity.

Growth hormone deficiency can cause decreased bone mineral density, which is associated with an increased risk of fractures. Quality of life can also be affected, resulting in depressed mood, reduced concentration, increased anxiety, fatigue and low self-esteem.