27th June 2023

Pre-exposure prophylaxis

The most common PrEP regimen is tenofovir with emtricitabine. The following groups are currently recommended to have PrEP after consideration of risk assessment in conjunction with tertiary sexual health services:

• Men who have sex with men who are assessed to have high risk and have had recent ongoing condomless anal sex (i.e. within the previous six months).
• People who are having condomless sex with a partner who is HIV positive, unless the partner has been on ART for >6 months and has a viral load lower than 200 copies/mL.
• Others who on sexual history and medical history are assessed to have an increased risk of HIV otherwise.

PrEP is given with different dosing regimens can be considered in different patients:

• Daily dosing for insertive and receptive anal and vaginal sex
• On-demand dosing (4 or more tablets around sexual activity) for people involved in anal sex
• Intermittent dosing (4 or more tablets prior to and after sex) for people involved in anal sex