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10th July 2023
Pyoderma Gangrenosum (PG)
PG presents clinically as painful, deep red necrotic ulcerating lesions with a violaceous border that mainly affects the lower extremities. Underlying medical disease is noted in approximately 50% of these patients, namely inflammatory bowel disease, rheumatoid arthritis, SLE and myeloid leukaemia. PG can characteristically cause peristomal complications in inflammatory bowel disease. Treatment involves oral steroid supplementation. PG is not typically associated with diabetes.
| System | Medical Conditions associated with PG |
|---|---|
| Gastroenterology | Ulcerative colitis
Crohn’s colitis |
| Hepatology | Chronic active hepatitis
Primary biliary cirrhosis Sclerosing cholangitis |
| Rheumatology | Rheumatoid arthritis
Ankylosing spondylitis |
| Haematology | Lymphoma
Leukaemia Myeloproliferative disorders |
| Other | Diabetes mellitus
Thyroid disease Sarcoidosis Wegener’s granulomatosis Other malignancies |
Table 4: Medical conditions associated with PG
Pyoderma gangrenosum
Image Source: Wikimedia Commons (2008). Crohnie Pyoderma gangrenosum, Licensed under a creative commons licence. Available for free at: https://commons.wikimedia.org/wiki/File:Crohnie_Pyoderma_gangrenosum.jpg (Accessed on: 16 July 2022).
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