15th March 2024

Glycopeptides

Glycopeptides such as vancomycin, dalbavancin and teicoplanin work by binding to transpeptidases (d-alanyl-d-alanine), which are required for cross-linking the cell wall. They have activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).

When used, there is an increased risk of nephrotoxicity, ototoxicity, thrombophlebitis and adverse skin reactions including SJS/TEN. Vancomycin has been associated with an infusion-related reaction named vancomycin flushing syndrome (VFS), leading to an erythematous rash affecting the upper body, pruritus and hypotension.