Antiarrhythmic medications | Medibuddy
24th April 2024

Antiarrhythmic medications

The development of new medications to treat arrhythmias and a greater understanding of the underlying mechanisms of current medicines, means there is often an overlap between categories. Amiodarone for example, is a class III antiarrhythmic that blocks potassium channels but also sodium and calcium channels (see Table 1). 

Class Examples Primary mechanism of action Additional points
Ia Quinidine

Procainamide

Disopyramide

Block Na+ channels (moderate) Prolongs action potential (AP) duration, which prolong QTc interval
Ib Lidocaine

Phenytoin

Block Na+ channels (weak) Shortens AP duration
Ic Flecainide

Propafenone

Block Na+ channels (strong) Prolongs AP but no effect on QTc interval
II Atenolol

Bisoprolol

Misoprolol

Beta blockers
III Amiodarone

Sotalol

Potassium channel blockers Prolong AP duration
IV Diltiazem

Verapamil

Non-dihydropyridine calcium channel blockers

Table 1: Vaugh-Williams classification of antiarrhythmic medicines.

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