Differential Diagnoses | Medibuddy
2nd August 2023

Differential Diagnoses

Whilst infection is responsible for most pyrexial scenarios, other strong contributors include malignancy (especially lymphomas) and connective tissue diseases such as rheumatoid arthritis and Kawasaki disease (see table 3). Be astute to not be caught out by the occult pulmonary embolism or drug induced fever – ironically, antimicrobials and anti-epileptics are chief culprits here.

Non-Infectious Inflammatory Causes Malignancy / Neoplastic Causes Miscellaneous
  • Giant Cell Arteritis
  • Rheumatoid Arthritis
  • Adult Still Disease
  • Antiphospholipid Syndrome
  • Gout
  • Pseudogout
  • Felty Syndrome
  • Sarcoidosis
  • Takayasu Arteritis
  • Systemic Lupus Erythematosus
  • Behçet’s disease
  • Granulomatosis with polyangiitis
  • Lymphoma
  • Renal Cell Carcinoma
  • Myeloproliferative Disorder
  • Multiple Myeloma
  • Atrial Myxoma
  • Metastatic Disease
  • Malignant histiocytosis
  • Breast / Liver / Pancreatic Cancer
  • Cirrhosis
  • Pulmonary embolism
  • Thyroiditis
  • Inflammatory Bowel Disease
  • Hypothalamic Syndrome
  • Drug induced fever
  • Factitious Fever

Table 3: A broad overview of non-infective causes of FUO

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