21st July 2023

A 13-year-old girl undergoes genetic screening for HNPCC after her mother and maternal grandmother both developed early onset colorectal cancer

A 13-year-old girl undergoes genetic screening for HNPCC after her mother and maternal grandmother both developed early onset colorectal cancer. Molecular genetic testing reveals a mutation in the mismatch repair gene MSH6, in keeping with a diagnosis of HNPCC. The geneticist explains that she will require surveillance endoscopies to screen for the development of colon adenomas and adenocarcinomas.

At what age will surveillance endoscopies need to start for this patient?

Select the SINGLE most appropriate option from the list below. Select ONE option only.