20th February 2024

A 22-year-old male had been referred to the cardiology clinic with a new murmur

A 22-year-old male had been referred to the cardiology clinic with a new murmur. On examination, a pan systolic murmur is heard and is loudest over the left parasternal edge. His JVP is not raised. He has a low nasal bridge with low-set ears. He is found to have a single palmar crease with shortened fingers along with up-slanting palpebral fissures.

There is no clear parental medical history, and previous genetic tests on the parents showed no chromosomal abnormalities, including a normal karyotype.

Which of the following phases of cell division is most likely to have been affected, resulting in the underlying disorder?

Select the SINGLE most appropriate option from the list below. Select ONE option only.