11th July 2023

A 25-year-old man presents with palmoplantar thickening

A 25-year-old man presents with palmoplantar thickening. His uncle and brother both have similar changes on their palms and soles. On examination of his oral cavity, you notice white plaque like lesions. Given these findings and positive family history, you suspect a diagnosis of Howel-Evans syndrome.

Which of the following malignancies are most associated with this syndrome?

Select the SINGLE most appropriate option from the list below. Select ONE option only.