1st July 2023

A 27-year-old woman presents with recurrent periorbital and tongue swelling. There is associated abdominal pain and vomiting

A 27-year-old woman presents with recurrent periorbital and tongue swelling. There is associated abdominal pain and vomiting. She has had recurrent episodes over the last 15 years which self-resolve after a few hours. Her past medical history includes depression for which she takes sertraline. Routine blood tests and tryptase levels are normal.

Given the most likely diagnosis, what is the underlying pathophysiology?

Select the SINGLE most appropriate option from the list below. Select ONE option only.