15th February 2024

A 32-year-old female presents to the immunology clinic with recurrent sinusitis and pneumonia throughout childhood

A 32-year-old female presents to the immunology clinic with recurrent sinusitis and pneumonia throughout childhood. She also had a poor response to her previous vaccination attempts. Examination revealed splenomegaly. She had imaging changes in keeping with bronchiectasis. Blood tests showed reduced levels of all immunoglobulins with normal white cell counts.

Which of the following is the likely underlying diagnosis?

Select the SINGLE most appropriate option from the list below. Select ONE option only.