18th February 2024

A 34-year-old female had presented to the acute medical unit with cellulitis and was commenced on flucloxacillin

A 34-year-old female had presented to the acute medical unit with cellulitis and was commenced on flucloxacillin. She began to experience fevers and malaise 24 hours after commencing her antibiotics. 4 days later, this progressed into a widespread erythematous rash and painful erosions involving her oral mucosa, trunk and extremities, involving approximately 40% of her body surface area. Nikolsky’s sign was positive on examination.

Given the likely diagnosis, which hypersensitivity reaction is the underlying pathogenesis for this condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.