19th February 2024

A 34-year-old female presents to the acute medical unit with a 24-hour history of fevers

A 34-year-old female presents to the acute medical unit with a 24-hour history of fevers and confusion. She denies any cough, dysuria, diarrhoea or abdominal pain. Her sister states that she was well yesterday when she attended the X-ray department for a CT scan with contrast.

She had a fever of 40.5ᵒC along with an HR of 150 bpm. She was diaphoretic, flushed and agitated. Chest examination revealed bibasal crepitations. A neck examination reveals a diffuse swelling in her anterior neck extending across the midline. ECG reveals atrial fibrillation.

Considering the likely underlying diagnosis resulting from this condition, which autoantibodies are associated with the underlying diagnosis?

Select the SINGLE most appropriate option from the list below. Select ONE option only.