4th March 2024

A 34-year-old woman has a past medical history of prolactinoma and was admitted to the acute medical unit

A 34-year-old woman has a past medical history of prolactinoma and was admitted to the acute medical unit with severe epigastric pain. She was seen by her GP and commenced on omeprazole for her epigastric pain, but this did not settle her pain despite being on 40mg twice daily of omeprazole. She also reports an episode of haematemesis with melaena. A subsequent OGD revealed three duodenal ulcers, and this was managed with thermal coagulation. Reviewing her medical notes, you note that she has had several previous duodenal ulcers needing treatment with endoscopy.

Blood tests performed on admission were as follows:

What is the underlying gene mutation that has resulted in her condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.