A 36-year-old female presents to ED following an episode of haemoptysis | Medibuddy
29th May 2023

A 36-year-old female presents to ED following an episode of haemoptysis

A 36-year-old female presents to ED following an episode of haemoptysis. She is generally unwell, and examination reveals widespread mucosal and subcutaneous bleeding. Her bloods on arrival show:

Hb 66 g/L (120-170 g/L)
WCC 5.1 x 10^9/L (3.6-11 x 10^9/L)
Neutrophils 0.7 x 10^9/L (1.8-7.5 x 10^9/L)
Platelets 8 x 10^9/L (150-400 x 10^9/L)
Film comment Confirmed anaemia and thrombocytopenia. Blasts present – hypergranulated cytoplasm with very frequent Auer rods.
PT 25 seconds (10-14 seconds)
APTT 51 seconds (22-36 seconds)
Fibrinogen <0.5 g/L (1.5-4.5 g/L)
D-dimer 8000 ng/ml (<500 ng/ml)

Urgent cytogenetic tests are sent. Given the likely diagnosis, what abnormality would you expect to find?

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