28th May 2023

A 38-year-old man is undergoing MATRIX chemotherapy for high-grade CNS lymphoma

A 38-year-old man is undergoing MATRIX chemotherapy for high-grade CNS lymphoma. He is seen on the acute haematology unit with nosebleeds. His platelets are found to be 9×10^9/L. He is given a pool of platelets. Part-way through the transfusion he develops an urticarial rash but is otherwise comfortable. He has not experienced these symptoms before. The transfusion is stopped and he is assessed.

What is the most appropriate next step in management of this patient?

Select the SINGLE most appropriate option from the list below. Select ONE option only.