7th August 2023

A 41 year old man returns from Burkina Faso feeling unwell with headaches, fevers, and malaise.

A 41 year old man returns from Burkina Faso feeling unwell with headaches, fevers, and malaise. He has splenomegaly on examination and is hypotensive and tachycardic. Bloods show a haemoglobin of 89 (low), platelet count of 133 (low) and a pH of 7.27 (low). He goes on to have a tonic-clonic seizure, is intubated and is transferred to intensive care. A blood film shows Plasmodium falciparum with a parasitaemia of 3%.

What is the first line treatment?

Select the SINGLE most appropriate option from the list below. Select ONE option only.