5th February 2024

A 43-year-old male is diagnosed with colorectal cancer. He underwent the FOLFOX chemotherapy

A 43-year-old male is diagnosed with colorectal cancer. He underwent the FOLFOX chemotherapy regime ( 5-fluorouracil, folinic acid and oxaliplatin) as the regime of choice. Following three cycles, he noted numbness and tingling affecting his hands and feet without any motor symptoms. Blood tests were unremarkable. It was felt that his chemotherapy agents were the likely cause.

Given the most likely causative agent, which of the following cell cycle phases does this medication exert its action?

Select the SINGLE most appropriate option from the list below. Select ONE option only.