19th February 2024

A 43-year-old male presents to the acute medical unit with generalised oedema

A 43-year-old male presents to the acute medical unit with generalised oedema, reduced urine output and haematuria. He was diagnosed with tonsillitis two weeks ago and treated with antibiotics. Examination reveals facial and lower limb oedema. His blood pressure measures 150/80mmHg. CXR confirms the presence of fluid overload. Urinalysis revealed 4+ blood and protein. Blood tests revealed significantly raised urea and creatinine. ASOT titres were significantly raised along with low C3 levels. Anti-GBM antibodies were negative. Renal biopsy reveals diffuse hypercellular glomeruli with neutrophil infiltration.

Given the likely diagnosis, which hypersensitivity reaction is the underlying pathogenesis for this condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.