5th February 2024

A 45-year-old female presented with non-Hodgkin’s lymphoma and was commenced on R-CHOP

A 45-year-old female presented with non-Hodgkin’s lymphoma and was commenced on R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone) chemotherapy. 2-days after commencing her treatment, she noted her urine was bright red with associated suprapubic tenderness. Cystoscopy showed petechial haemorrhage of the bladder mucosa with hyperaemia and bladder clots.

Given the likely cause of her haematuria, which cell cycle phase does this agent act on?

Select the SINGLE most appropriate option from the list below. Select ONE option only.