19th February 2024

A 45-year-old female presents with weight loss and shortness of breath on minimal exertion

A 45-year-old female presents with weight loss and shortness of breath on minimal exertion. An echocardiogram at the time showed severely impaired systolic function in keeping with cardiomyopathy without evidence of pulmonary hypertension. She also experienced GORD and dysphagia. She has been diagnosed with Raynaud’s phenomenon in the past. CT chest confirmed fibrotic changes in both lower lobes. Both hands showed thickened, shiny fingers with clawing of fingers. Facial and truncal skin tightening, along with facial telangiectasia, were noted.

Given the likely diagnosis, which autoantibodies will likely be positive?

Select the SINGLE most appropriate option from the list below. Select ONE option only.