5th February 2024

A 47-year-old male was diagnosed with Hodgkin’s lymphoma and commenced a chemotherapy regimen of bleomycin

A 47-year-old male was diagnosed with Hodgkin’s lymphoma and commenced a chemotherapy regimen of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine and procarbazine. It was felt that one of the chemotherapy agents (an M-phase specific chemotherapy agent) resulted in the patient’s peripheral neuropathy after three cycles of chemotherapy.

Given the likely culprit agent, which of the following is the mechanism of action of this medication?

Select the SINGLE most appropriate option from the list below. Select ONE option only.