24th July 2023

A 48-year-old woman presents with a 2-month history of weight loss and loss of appetite

A 48-year-old woman presents with a 2-month history of weight loss and loss of appetite. She reports a constant “itching all over” feeling, and has made this GP appointment as her partner noticed she “looks a bit yellow”. She has no past medical history of note but tells you her twin sister and brother both have “diseases to do with their immune system”.

Subsequent imaging reveals a tumour in the common bile duct.

Which of the following conditions is most likely to be a risk factor in this case?

Select the SINGLE most appropriate option from the list below. Select ONE option only.