5th February 2024

A 56-year-old female has been diagnosed with pancreatic cancer. She was prescribed FOLFIRINOX

A 56-year-old female has been diagnosed with pancreatic cancer. She was prescribed FOLFIRINOX ( Folinic acid, 5-fluorouracil, irinotecan and oxaliplatin) as her chemotherapy regime. On admission for her fourth chemotherapy session, she reported increasing pins and needle sensations in her upper and lower limbs. This was not associated with significant weakness. Blood tests were normal, with no significant electrolyte, TFT or vitamin B abnormalities.

Given the likely cause, which of the following best describes the mode of action of the causative agent?

Select the SINGLE most appropriate option from the list below. Select ONE option only.