19th February 2024

A 56-year-old male presents to the acute medical unit with severe muscle weakness

A 56-year-old male presents to the acute medical unit with severe muscle weakness. He cannot lift objects onto cupboards above arm height and struggles to walk uphill. He has also struggled to stand from a chair. He notes pain along his thighs, shoulders and neck. Examination reveals weakness in his shoulders and thighs with a power of 3/5. Sensory examination was normal. Bilateral crepitations were heard on examination of his lungs. No rash was identified. CXR reveals fine reticular changes at his lung bases with mild volume loss. Bloods showed elevated creatinine kinase levels.

Which of the following autoantibodies can be associated with this clinical picture?

Select the SINGLE most appropriate option from the list below. Select ONE option only.