5th February 2024

A 60-year-old female presents with progressive shortness of breath and reduced exercise tolerance

A 60-year-old female presents with progressive shortness of breath and reduced exercise tolerance. Her only past medical history was Hodgkin’s lymphoma localised to her chest. This was managed with chemotherapy ( vincristine, bleomycin, doxorubicin, procarbazine, cyclophosphamide and prednisolone) 2 years ago. The echocardiogram showed an LVEF of 30% (previously normal). She has normal coronary arteries on further investigation. It was felt this was an adverse reaction to her chemotherapy agents.

Given the likely culprit agent, which of the following is the mechanism of action of this medication?

Select the SINGLE most appropriate option from the list below. Select ONE option only.