10th January 2024

A 60-year-old lady with a history of diabetes mellitus, chronic kidney disease, and smoking

A 60-year-old lady with a history of diabetes mellitus, chronic kidney disease, and smoking presents due to a change in bowel habit with a positive FIT test. A colonoscopy reveals a colorectal carcinoma at the hepatic flexure, and she is commenced on chemotherapy.

After one cycle of chemotherapy, she reports painful electrical shocks in her lower limb and has noticed injuries to her feet without a clear mechanism. Examination reveals sensory loss in a stocking distribution and two foot ulcers.

What is the most likely cause of her peripheral neuropathy?

Select the SINGLE most appropriate option from the list below. Select ONE option only.