19th February 2024

A 65-year-old male presents to the acute medical unit with a seven-month history of weakness

A 65-year-old male presents to the acute medical unit with a seven-month history of weakness. He experienced increased falls and is unable to climb upstairs. His weakness eases once he starts walking. He also described dry mouth, constipation and reduced libido. On examination, he demonstrated a Trendelenburg gait and could not stand from a chair unassisted. Deep reflexes in the legs were very sluggish but improved after physical exertion. Mild ptosis was noted bilaterally.

Given the underlying diagnosis, which autoantibodies likely contribute to this condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.