6th March 2024

A 67 year old gentleman with gout, depression, obesity hypoventilation syndrome and established HFrEF, is admitted to hospital with decompensated heart failure.

A 67 year old gentleman with gout, depression, obesity hypoventilation syndrome and established HFrEF, is admitted to hospital with decompensated heart failure. His medication list includes allopurinol, sertraline, sacubitril/valsartan, empagliflozin, eplerenone, bisoprolol and bumetanide. He is commenced on a furosemide infusion over 24 hours and his bumetanide is held.  What is the mechanism of action for furosemide?

Select the SINGLE most appropriate option from the list below. Select ONE option only.