A 68-year-old male presents to the haematology clinic with a 3-month history of fevers
A 68-year-old male presents to the haematology clinic with a 3-month history of fevers, sweats and dull abdominal pains. He has noted some abdominal distension as well. He denies any cough, shortness of breath, sputum, urinary symptoms or change in bowel habits. Examination revealed palpable splenomegaly. No palpable lymphadenopathy was detected.
Blood tests were performed with the following results:
| Blood test | Value | Normal range |
|---|---|---|
| Hb | 120g/L | 130-180g/L |
| WCC | 54.7 x10⁹/L | 4.0-11.0 x10⁹/L |
| Platelets | 170 x10⁹/L | 140-400 x10⁹/L |
A blast count of 1.2% was reported. Cell count differential reveals raised basophil and eosinophil counts. Raised neutrophil counts with the presence of myelocytes were noted. Bone marrow biopsy showed hypercellularity with myeloid hyperplasia.
Which of the following oncogenes has likely resulted in the condition?
Select the SINGLE most appropriate option from the list below. Select ONE option only.
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