19th February 2024

A 70-year-old female presents to the acute medical unit with unsteadiness

A 70-year-old female presents to the acute medical unit with unsteadiness. Her symptoms began six weeks ago with dizziness and nausea. Over two weeks, this rapidly progressed to difficulty maintaining her walking balance. Her speech was becoming increasingly slurred. On examination, she was unable to maintain truncal stability while sitting. A wide-based gait was seen. Scanning speech was noted. She had bilateral past pointing and dysdiadokokinesia. CT scan of her body revealed a thickened endometrial lining, and the patient notes a 3-month history of PV bleeding, bloating and weight loss.

Which of the following autoantibodies MOST likely contributed to the underlying diagnosis?

Select the SINGLE most appropriate option from the list below. Select ONE option only.