20th July 2023

A 73-year-old woman is diagnosed with major depressive disorder.

A 73-year-old woman is diagnosed with major depressive disorder. Her past medical history includes hypertension, previous neck of femur fracture, osteoarthritis, and diverticular disease.

Drug history: amlodipine 10mg once daily, calcium carbonate + colecalciferol 1500mg/400iu twice daily, paracetamol 1g 6 hourly PRN. She has no known allergies.

What would be the most appropriate pharmacological agent to manage her depression?

Select the SINGLE most appropriate option from the list below. Select ONE option only.