18th February 2024

A 74-year-old male presents with a blistering rash

A 74-year-old male presents with a blistering rash. This began three weeks ago with urticaria and itch throughout his body. The rash appeared a week before admission, with 1-2cm tense blisters along his trunk and arms. These blisters do not easily rupture and heal without scarring. Nikolsky’s sign is negative.

Given the likely diagnosis, which hypersensitivity reaction is the underlying pathogenesis for this condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.