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30th May 2023
A 77-year-old male is admitted under the medical team with severe fatigue and weight loss
A 77-year-old male is admitted under the medical team with severe fatigue and weight loss. He appears generally unkempt and admits he has neglected his health for several years after the death of his wife. Examination reveals massive splenomegaly.
His bloods are as follows:
| Hb | 76 g/L | (130-180 g/L) |
| WCC | 41 x 10⁹/L | (3.6-11 x 10⁹/L) |
| Platelets | 72 x 10⁹/L | (150-400 x 10⁹/L) |
| Neutrophils | 16 x 10⁹/L | (1.8-7.5 x 10⁹/L) |
| Lymphocytes | 1 x 10⁹/L | (1.0-4.0 x 10⁹/L) |
| Basophils | 11 x 10⁹/L | (0.02-0.10 x 10⁹/L) |
| Eosinophils | 3.5 x 10⁹/L | (0.1-0.4 x 10⁹/L) |
| Monocytes | 0.3 x 10⁹/L | (0.2-0.8 x 10⁹/L) |
| Blood film report | Leukocytosis with blasts present – 18%. | |
What is the most likely diagnosis?
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