19th February 2024

A 78-year-old female presents to the rheumatology clinic with multiple joint swelling

A 78-year-old female presents to the rheumatology clinic with multiple joint swelling, tightening of her fingers and face skin and Raynaud’s phenomenon. She describes associated dysphagia and shortness of breath on minimal exertion. Examination revealed generalised oedema. An echocardiogram showed evidence of pulmonary hypertension. Elevated CK levels were detected on blood tests. Anti-U1-RNP antibodies were positive.

Which of the following is the likely underlying diagnosis?

Select the SINGLE most appropriate option from the list below. Select ONE option only.